VARIATION IN BREEDING PRACTICES AND GEOGRAPHIC ISOLATION DRIVE SUBPOPULATION DIFFERENTIATION, CONTRIBUTING TO THE LOSS OF GENETIC DIVERSITY WITHIN DOG BREED LINEAGES

Variation in breeding practices and geographic isolation drive subpopulation differentiation, contributing to the loss of genetic diversity within dog breed lineages

Abstract Background Discrete breed ideals are not restricted to delimiting dog breeds from another, but also are key drivers of subpopulation differentiation.As genetic differentiation due to population fragmentation results in increased rates of inbreeding and loss of genetic diversity, detecting and alleviating the reasons of population fragmenta

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A Single-Domain Antibody Targeting Complement Component C5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Terminal Domain of the Staphylococcus aureus SSL7 Protein

The complement system is an efficient anti-microbial effector mechanism.On the other hand abnormal complement activation is involved in the pathogenesis of multiple inflammatory and hemolytic diseases.As general inhibition chocolate chip cookie purse of the complement system may jeopardize patient health due to increased susceptibility to infection

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